Showing posts with label M. Show all posts
Showing posts with label M. Show all posts

Morphine

Morphine is the principal constituent of opium and can range in concentration from 4 to 21 percent. Commercial opium is standardized to contain 10-percent morphine. In the United States, a small percentage of the morphine obtained from opium is used directly (about 15 tons): the remaining is converted to codeine and other derivatives (about 120 tons). Morphine is one of the most effective drugs known for the relief of severe pain and remains the standard against which new analgesics are measured. Like most narcotics, the use of morphine has increased significantly in recent years. Since 1990, there has been about a 3-fold increase in morphine products in the United States.

Morphine is marketed under generic and brand name products including "MS-Contin®," Oramorph SR®," MSIR®," Roxanol®," Kadian®," and RMS®." Morphine is used parenterally (by injection) for preoperative sedation, as a supplement to anesthesia, and for analgesia. It is the drug of choice for relieving pain of myocardial infarction and for its cardiovascular effects in the treatment of acute pulmonary edema. Traditionally; morphine was almost exclusively used by injection. Today, morphine is marketed in a variety of forms, including oral solutions, immediate and sustained-release tablets and capsules, suppositories, and injectable preparations. In addition, the availability of high-concentration morphine preparations (i.e., 20-mg/ml oral solutions, 25-mg/ml injectable solutions, and 200-mg sustained-release tablets) partially reflects the use of this substance for chronic pain management in opiate-tolerant patients.
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Methamphetamine

Methamphetamine is a powerful stimulant that activates certain systems in the brain. It is closely related chemically to amphetamine, but the central nervous system effects of methamphetamine are greater. Both drugs have some medical uses, primarily in the treatment of obesity, but their therapeutic use is limited. The central nervous system (CNS) actions that result from taking even small amounts of methamphetamine include increased wakefulness, increased physical activity, decreased appetite, increased respiration, hypethermia, and euphoria. Other CNS effects include irritability, insomnia, confusion, tremors, convulsions, anxiety, paranoia, and aggressiveness. Hyperthermia and convulsions can result in death.

Illicit methamphetamine, which is almost exclusively methamphetamine hydrochloride, is sold in powder, ice, and tablet forms. Powder methamphetamine, the most common form available in the United States, is produced domestically and also is smuggled into the country from Mexico. Traditionally, Asian-produced ice was almost exclusively found in Guam, Hawaii, and parts of California; however, increased domestic production of this form of methamphetamine has increased availability to several other areas of the country previously untouched by exposure to ice. Methamphetamine tablets, primarily manufactured in Burma, have been smuggled into the United States, especially to northern California and the Los Angeles area.

Source: DEA, "Drug Intelligence Brief: The Forms of Methamphetamine," April 2002

Methamphetamine is also known as "speed" or "crystal" when it is swallowed or sniffed; as "crank" when it is injected; and as "ice" or "glass" when it is smoked.

Ice is clear chunky crystal form of meth that resembles "ice."

YABA: Thai for "crazy medicine," Yaba, a methamphetamine tablet, has been appearing in the United States. Yaba tablets are sometimes flavored (grape, orange, and vanilla): tasting like candy, the tablets are obviously marketed to a young audience, particularly at rave’s or parties where Ecstasy (a similar looking drug) has been well established. The tablets are commonly reddish-orange or green, and fit inside the end of a drinking straw. They have a variety of logos, with “WY” the most common. Methamphetamine pills are normally ingested orally, although they can be crushed into powder and administered.

All forms of methamphetamine are extremely dangerous and induce long-lasting, debilitating effects.

Meth Labs are a growing problem throughout the country (US). Click here to learn about how methamphetamine is made and to learn how to spot a lab.

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Methylphenidate (Ritalin)

Methylphenidate, a Schedule II substance, has a high potential for abuse and produces many of the same effects as cocaine or amphetamine. The abuse of this substance has been documented among narcotic addicts who dissolve the tablets in water and inject the mixture. Complications arising from this practice are common due to the insoluble fillers used in the tablets. When injected, these materials block small blood vessels, causing serious damage to the lungs and retina of the eye. Binge use, psychotic episodes, cardiovascular complications, and severe psychological addiction have all been associated with methylphenidate abuse.

Methylphenidate is used legitimately in the treatment of excessive daytime sleepiness associated with narcolepsy, as is the newly marketed Schedule IV stimulant, modafinil (Provigil®). However; the primary legitimate medical use of methylphenidate (Ritalin®, Methylin®, Concerta®) is to treat attention deficit hyperactivity disorder (ADHD) in children. The increased use of this substance for the treatment of ADHD has paralleled an increase in its abuse among adolescents and young adults who crush these tablets and snort the powder to get high. Youngsters have little difficulty obtaining methylphenidate from classmates or friends who have been prescribed it. Greater efforts to safeguard this medication at home and school are needed.

Source: DEA
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Methcathinone

Methcathinone, known on the streets as "Cat," is a structural analogue of methamphetamine and cathinone. Clandestinely manufactured, methcathinone is almost exclusively sold in the stable and highly water soluble hydrochloride salt form. It is most commonly snorted, although it can be taken orally by mixing it with a beverage or diluted in water and injected intravenously. Methcathinone has an abuse potential equivalent to methamphetamine and produces amphetamine-like activity. It was placed in Schedule I of the CSA in 1993.

Source: DEA

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Methamphetamine

Methamphetamine is a powerful stimulant that activates certain systems in the brain. It is closely related chemically to amphetamine, but the central nervous system effects of methamphetamine are greater. Both drugs have some medical uses, primarily in the treatment of obesity, but their therapeutic use is limited. The central nervous system (CNS) actions that result from taking even small amounts of methamphetamine include increased wakefulness, increased physical activity, decreased appetite, increased respiration, hypethermia, and euphoria. Other CNS effects include irritability, insomnia, confusion, tremors, convulsions, anxiety, paranoia, and aggressiveness. Hyperthermia and convulsions can result in death.

Illicit methamphetamine, which is almost exclusively methamphetamine hydrochloride, is sold in powder, ice, and tablet forms. Powder methamphetamine, the most common form available in the United States, is produced domestically and also is smuggled into the country from Mexico. Traditionally, Asian-produced ice was almost exclusively found in Guam, Hawaii, and parts of California; however, increased domestic production of this form of methamphetamine has increased availability to several other areas of the country previously untouched by exposure to ice. Methamphetamine tablets, primarily manufactured in Burma, have been smuggled into the United States, especially to northern California and the Los Angeles area.

Source: DEA, "Drug Intelligence Brief: The Forms of Methamphetamine," April 2002

Methamphetamine is also known as "speed" or "crystal" when it is swallowed or sniffed; as "crank" when it is injected; and as "ice" or "glass" when it is smoked.

Ice is clear chunky crystal form of meth that resembles "ice."

YABA: Thai for "crazy medicine," Yaba, a methamphetamine tablet, has been appearing in the United States. Yaba tablets are sometimes flavored (grape, orange, and vanilla): tasting like candy, the tablets are obviously marketed to a young audience, particularly at rave’s or parties where Ecstasy (a similar looking drug) has been well established. The tablets are commonly reddish-orange or green, and fit inside the end of a drinking straw. They have a variety of logos, with “WY” the most common. Methamphetamine pills are normally ingested orally, although they can be crushed into powder and administered.

All forms of methamphetamine are extremely dangerous and induce long-lasting, debilitating effects.

Meth Labs are a growing problem throughout the country (US). Click here to learn about how methamphetamine is made and to learn how to spot a lab.

-->Read more...

Methamphetamine

Methamphetamine is a powerful stimulant that activates certain systems in the brain. It is closely related chemically to amphetamine, but the central nervous system effects of methamphetamine are greater. Both drugs have some medical uses, primarily in the treatment of obesity, but their therapeutic use is limited. The central nervous system (CNS) actions that result from taking even small amounts of methamphetamine include increased wakefulness, increased physical activity, decreased appetite, increased respiration, hypethermia, and euphoria. Other CNS effects include irritability, insomnia, confusion, tremors, convulsions, anxiety, paranoia, and aggressiveness. Hyperthermia and convulsions can result in death.

Illicit methamphetamine, which is almost exclusively methamphetamine hydrochloride, is sold in powder, ice, and tablet forms. Powder methamphetamine, the most common form available in the United States, is produced domestically and also is smuggled into the country from Mexico. Traditionally, Asian-produced ice was almost exclusively found in Guam, Hawaii, and parts of California; however, increased domestic production of this form of methamphetamine has increased availability to several other areas of the country previously untouched by exposure to ice. Methamphetamine tablets, primarily manufactured in Burma, have been smuggled into the United States, especially to northern California and the Los Angeles area.

Source: DEA, "Drug Intelligence Brief: The Forms of Methamphetamine," April 2002

Methamphetamine is also known as "speed" or "crystal" when it is swallowed or sniffed; as "crank" when it is injected; and as "ice" or "glass" when it is smoked.

Ice is clear chunky crystal form of meth that resembles "ice."

YABA: Thai for "crazy medicine," Yaba, a methamphetamine tablet, has been appearing in the United States. Yaba tablets are sometimes flavored (grape, orange, and vanilla): tasting like candy, the tablets are obviously marketed to a young audience, particularly at rave’s or parties where Ecstasy (a similar looking drug) has been well established. The tablets are commonly reddish-orange or green, and fit inside the end of a drinking straw. They have a variety of logos, with “WY” the most common. Methamphetamine pills are normally ingested orally, although they can be crushed into powder and administered.

All forms of methamphetamine are extremely dangerous and induce long-lasting, debilitating effects.

Meth Labs are a growing problem throughout the country (US). Click here to learn about how methamphetamine is made and to learn how to spot a lab.

-->Read more...

Methadone

German scientists synthesized methadone during World War II because of a shortage of morphine. Although chemically unlike morphine or heroin, methadone produces many of the same effects. Introduced into the United States in 1947 as an analgesic (Dolophinel), it is primarily used today for the treatment of narcotic addiction. It is available in oral solutions, tablets, and injectable Schedule II formulations, and is almost as effective when administered orally as it is by injection. Methadone's effects can last up to 24 hours, thereby permitting once-a-day oral administration in heroin detoxification and maintenance programs. High-dose methadone can block the effects of heroin, thereby discouraging the continued use of heroin by addicts under treatment with methadone. Chronic administration of methadone results in the development of tolerance and dependence. The withdrawal syndrome develops more slowly and is less severe but more prolonged than that associated with heroin withdrawal. Ironically, methadone used to control narcotic addiction is frequently encountered on the illicit market and has been associated with a number of overdose deaths.

Source: DEA

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Mescaline (Peyote and San Pedro Cacti)

Peyote is a small, spineless cactus, Lophophora williamsii, whose principal active ingredient is the hallucinogen mescaline (3, 4, 5-trimethoxyphenethylamine). From earliest recorded time, peyote has been used by natives in northern Mexico and the southwestern United States as a part of their religious rites.

The top of the cactus above ground--also referred to as the crown--consists of disc-shaped buttons that are cut from the roots and dried. These buttons are generally chewed or soaked in water to produce an intoxicating liquid. The hallucinogenic dose of mescaline is about 0.3 to 0.5 grams and lasts about 12 hours. While peyote produced rich visual hallucinations that were important to the native peyote cults, the full spectrum of effects served as a chemically induced model of mental illness. Mescaline can be extracted from peyote or produced synthetically. Both peyote and mescaline are listed in the CSA as Schedule I hallucinogens.

Source: DEA

The San Pedro cactus, Trichocereus pachanoi, is native to the high Andes in Peru, South America. Like Peyote, its principle active ingredient is mescaline.

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Meprobamate

Meprobamate was introduced as an anti-anxiety agent in 1955 and is prescribed primarily to treat anxiety, tension, and associated muscle spasms. More than 50 tons are distributed annually in the United States under its generic name and brand names such as Miltown® and Equanil®. Its onset and duration of action are similar to the intermediate-acting barbiturates; however, therapeutic doses of meprobamate produce less sedation and toxicity than barbiturates. Excessive use can result in psychological and physical dependence. Carisoprodol (Soma®), a skeletal muscle relaxant, is metabolized to meprobamate. This conversion may account for some of the properties associated with carisoprodol and likely contributes to its abuse.

Source: DEA

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Meperidine

Introduced as an analgesic in the 1930s, meperidine produces effects that are similar, but not identical, to morphine (shorter duration of action and reduced antitussive and antidiarrheal actions). Currently it is used for pre-anesthesia and the relief of moderate to severe pain, particularly in obstetrics and post-operative situations. Meperidine is available in tablets, syrups, and injectable forms under generic and brand name (Demerol®, Mepergan®, etc.) Schedule II preparations. Several analogues of meperidine have been clandestinely produced. During the clandestine synthesis of the analogue MPPP, a neurotoxic by-product (MPTP) was produced. A number of individuals who consumed the MPPP-MPTP preparation developed an irreversible Parkinsonian-like syndrome. It was later found that MPTP destroys the same neurons as those damaged in the Parkinsonian-like syndrome. It was later found that MPTP destroys the same neurons as those damaged in Parkinsons Disease.

Source: DEA

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MDMA (Ecstasy)

MDMA abuse and the trafficking of MDMA is on the rise, posing serious social concerns. Once confined to major metropolitan areas, MDMA trafficking has now expanded to smaller communities. Teenagers and young adults continue to be the primary targets of sophisticated crime syndicates who are supplying distribution groups with ever-increasing amounts of MDMA tablets. As the trend to consume MDMA in tandem with alcohol and other drugs continues, the harmful effects of the drug will increase exponentially.

MDMA (3,4-methylenedioxy-N-methylamphetamine), also referred to as Ecstasy, XTC, Adam, and Essence, is a illegally manufactured variation of mescaline and amphetamine. It is considered a designer drug---a substance on the drug market that is a chemical analogue or variation of another psychoactive drug.

MDMA is marketed as a feel good drug. Devotees say it produces profoundly positive feelings, empathy for others, elimination of anxiety, and extreme relaxation--hence the nickname "hug drug," or "love drug." MDMA is also said to suppress the need to eat, drink, or sleep, enabling club scene users to endure all-night and sometimes two, or three-day parties.

MDMA is taken orally, usually in tablet or capsule form. MDMA tablets are often "stamped" with icons or logos intended to appeal to a young audience. Its effects last approximately four to six hours.

Tablets sold as Ecstasy are not always pure MDMA. As demand for Ecstasy has increased, so has the appearance of Ecstasy "fakes" often containing other substances such as amphetamine, caffeine, codeine, DXM, ephedra/ephedrine, ketamine, MDA, methamphetamine, and PCP. When used alone, MDMA is dangerous. It is even more dangerous when used in combination with other substances, as the physical and psychological effects are difficult to determine or predict.

SHORT TERM EFFECTS: increased heart rate, blood pressure and body temperature; jaw and teeth clenching/muscle tension, hypertension, dehydration, chills and/or sweating, nausea, blurred vision, faintness, dizziness, confusion, insomnia, and paranoia.

MEDICAL COMPLICATIONS:

LARGE DOSE:
muscle breakdown, hyperthermia, kidney failure and cardiovascular system failure.

LONG TERM USE:
depression, sleep disorders, paranoia, drug craving, persistent elevation of anxiety, liver damage, brain damage, paralysis, and possible others pending research.

Domestically, the DEA seized 196 MDMA tablets in 1993 and more than 3 million tablets in 2000. The amount of seizures made by Customs has increased from 400,000 in FY 1997 to 7.2 million in FY 2001.
Source: DEA, U.S. Customs Service



In 2001, MDMA use among young people jumped an additional 20 percent. Since 1999, teen MDMA use increased by 71 percent. More than 12 percent of teens report trying MDMA at least once in their lives---an increase from 10% in 2000 (a year-to-year increase of 20 percent), 7 percent in 1999 (a 71 percent increase to date) and 5 percent in 1995---an increase of 140 percent from 1995 to 2001.
Source: 2001 Partnership Attitude Tracking Study

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Marijuana

Marijuana is the most widely used illegal substance in the world today. It's use is also the most controversial. With legalization efforts underway, it is important to have the facts.

Marijuana is made from the plant cannabis sativa, a plant that grows wild (and is also cultivated indoors and out) throughout many regions. Most of the marijuana used in the United States comes from sources in the U.S., Mexico ("Mexican Red/Brown"), and Canada ("BC Bud").

Marijuana consists of the buds, leaves, and resin of the cannabis plant. The stalks and sterilized seeds are considered "hemp."

The plant, cannabis sativa, contains chemicals called "cannabinoids." THC (delta-9-tetrhydrocannabinol) is the cannabinoid believed to be responsible for the psychoactive effects of cannabis.

THC can be found in all parts of the cannabis plant, including hemp. This is why hemp is regulated carefully--some hemp products such as clothing, rope, yarn, lotion and soap are legal products because they do not cause THC to enter the human body.

"While most of the THC in cannabis plants is concentrated in the marijuana, all parts of the plant, including hemp, have been found to contain THC. The existence of THC in hemp is significant because THC, like marijuana, is a schedule I controlled substance." (Source: DEA)

Synthetic THC: Medical Marijuana already exists.

" A pharmaceutical product, Marinol, is widely available through prescription. It comes in the form of a pill and is also being studied by researchers for suitability via other delivery methods, such as an inhaler or patch. The active ingredient of Marinol is synthetic THC, which has been found to relieve the nausea and vomiting associated with chemotherapy for cancer patients and to assist with loss of appetite with AIDS patients. Another product, Cesamet, which is similar to Marinol, is to be released in the U.S. in June of 2006.

"There are no FDA-approved medications that are smoked. For one thing, smoking is generally a poor way to deliver medicine. It is difficult to administer safe, regulated dosages of medicines in smoked form. Secondly, the harmful chemicals and carcinogens that are byproducts of smoking create entirely new health problems. There are four times the level of tar in a marijuana cigarette, for example, than in a tobacco cigarette."
(Source: "Medical" Marijuana: The Facts, DEA)

"Smoking marijuana may increase the risk of cancer more than smoking tobacco. Marijuana smoke contains 50% to 70% more carcinogenic hydrocarbons than does tobacco smoke. It also produces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form--levels that may accelerate the canges that ultimately produce malignant cells." (Source: NIDA)

"It has been estimated that smoking a cannabis cigarette (containing only herbal cannabis) results in an approximately five-fold greater increase in carboxyhaemoglobin concentration, a three-fold greater increase in the amount of tar inhaled, and a retention in the respiratory tract of one third more tar than smoking a tobacco cigarette."
(Source: British Medical Association)

In May 2006, a study was published by UCLA that disputes the claims that marijuana causes lung cancer. To read the press release, click here >>

The majority of marijuana is smoked, although some users ingest it orally (added to brownies, cookies, etc.). Marijuana is usually smoked in the form of loosely rolled cigarettes called "joints," hollowed out commercial cigars called "blunts," smoked in pipes or bongs. Joints and blunts are sometimes laced with a number of adulterants including PCP, cocaine and embalming fluid (a chemical traditionally used to preserve dead bodies)--resulting in a wide range of effects

STREET TERMS for marijuana include pot, weed, grass, bud, dope and hydro.

SHORT TERM EFFECTS of marijuana use include impaired short-term memory, impaired concentration, attention, and judgment; impaired coordination and balance, increased heart rate, blood shot or red eyes, dry mouth and increased appetite (the "munchies").

* Occasional effects, especially with long term use, include anxiety, panic, and paranoia.

LONG TERM EFFECTS of marijuana use include addiction (psychological), paranoia, persistent anxiety, impaired learning skills and memory difficulties.

MEDICAL COMPLICATIONS associated with marijuana use include an increased risk of chronic cough, bronchitis, and emphysema; increased risk of cancer of the head, neck, and lungs; a decrease in testosterone levels and lower sperm counts for men and an increase in testosterone levels for women and increased risk of infertility.

Additional Information from NIDA:

* Within a few minutes after inhaling marijuana smoke, an individual's heart begins beating more rapidly, the bronchial passages relax and become enlarged, and blood vessels in the eyes expand, making the eyes look red. The heart rate, normally 70 to 80 beats per minute, may increase by 20 to 50 beats per minute or, in some cases, even double. This effect can be greater if other drugs are taken with marijuana.

* Studies show that approximately 6 to 11 percent of fatal accident victims test positive for THC. In many of these cases, alcohol is detected as well. In a study conducted by the National Highway Traffic Safety Administration, a moderate dose of marijuana alone was shown to impair driving performance; however, the effects of even a low dose of marijuana combined with alcohol were markedly greater than for either drug alone. Driving indices measured included reaction time, visual search frequency (driver checking side streets), and the ability to perceive and/or respond to changes in the relative velocity of other vehicles.

* Cancer of the respiratory tract and lungs may also be promoted by marijuana smoke. A study comparing 173 cancer patients and 176 healthy individuals produced strong evidence that smoking marijuana increases the likelihood of developing cancer of the head or neck, and that the more marijuana smoked, the greater the increase. A statistical analysis of the data suggested that marijuana smoking doubled or tripled the risk of these cancers.

* Marijuana has the potential to promote cancer of the lungs and other parts of the respiratory tract because it contains irritants and carcinogens.42 In fact, marijuana smoke contains 50 percent to 70 percent more carcinogenic hydrocarbons than does tobacco smoke.43 It also produces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form, levels that may accelerate the changes that ultimately produce malignant cells.44 Marijuana users usually inhale more deeply and hold their breath longer than tobacco smokers do, which increases the lungs' exposure to carcinogenic smoke. These facts suggest that, puff for puff, smoking marijuana may increase the risk of cancer more than smoking tobacco does.
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Marijuana

Marijuana is the most widely used illegal substance in the world today. It's use is also the most controversial. With legalization efforts underway, it is important to have the facts.

Marijuana is made from the plant cannabis sativa, a plant that grows wild (and is also cultivated indoors and out) throughout many regions. Most of the marijuana used in the United States comes from sources in the U.S., Mexico ("Mexican Red/Brown"), and Canada ("BC Bud").

Marijuana consists of the buds, leaves, and resin of the cannabis plant. The stalks and sterilized seeds are considered "hemp."

The plant, cannabis sativa, contains chemicals called "cannabinoids." THC (delta-9-tetrhydrocannabinol) is the cannabinoid believed to be responsible for the psychoactive effects of cannabis.

THC can be found in all parts of the cannabis plant, including hemp. This is why hemp is regulated carefully--some hemp products such as clothing, rope, yarn, lotion and soap are legal products because they do not cause THC to enter the human body.

"While most of the THC in cannabis plants is concentrated in the marijuana, all parts of the plant, including hemp, have been found to contain THC. The existence of THC in hemp is significant because THC, like marijuana, is a schedule I controlled substance." (Source: DEA)

Synthetic THC: Medical Marijuana already exists.

" A pharmaceutical product, Marinol, is widely available through prescription. It comes in the form of a pill and is also being studied by researchers for suitability via other delivery methods, such as an inhaler or patch. The active ingredient of Marinol is synthetic THC, which has been found to relieve the nausea and vomiting associated with chemotherapy for cancer patients and to assist with loss of appetite with AIDS patients. Another product, Cesamet, which is similar to Marinol, is to be released in the U.S. in June of 2006.

"There are no FDA-approved medications that are smoked. For one thing, smoking is generally a poor way to deliver medicine. It is difficult to administer safe, regulated dosages of medicines in smoked form. Secondly, the harmful chemicals and carcinogens that are byproducts of smoking create entirely new health problems. There are four times the level of tar in a marijuana cigarette, for example, than in a tobacco cigarette."
(Source: "Medical" Marijuana: The Facts, DEA)

"Smoking marijuana may increase the risk of cancer more than smoking tobacco. Marijuana smoke contains 50% to 70% more carcinogenic hydrocarbons than does tobacco smoke. It also produces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form--levels that may accelerate the canges that ultimately produce malignant cells." (Source: NIDA)

"It has been estimated that smoking a cannabis cigarette (containing only herbal cannabis) results in an approximately five-fold greater increase in carboxyhaemoglobin concentration, a three-fold greater increase in the amount of tar inhaled, and a retention in the respiratory tract of one third more tar than smoking a tobacco cigarette."
(Source: British Medical Association)

In May 2006, a study was published by UCLA that disputes the claims that marijuana causes lung cancer. To read the press release, click here >>

The majority of marijuana is smoked, although some users ingest it orally (added to brownies, cookies, etc.). Marijuana is usually smoked in the form of loosely rolled cigarettes called "joints," hollowed out commercial cigars called "blunts," smoked in pipes or bongs. Joints and blunts are sometimes laced with a number of adulterants including PCP, cocaine and embalming fluid (a chemical traditionally used to preserve dead bodies)--resulting in a wide range of effects

STREET TERMS for marijuana include pot, weed, grass, bud, dope and hydro.

SHORT TERM EFFECTS of marijuana use include impaired short-term memory, impaired concentration, attention, and judgment; impaired coordination and balance, increased heart rate, blood shot or red eyes, dry mouth and increased appetite (the "munchies").

* Occasional effects, especially with long term use, include anxiety, panic, and paranoia.

LONG TERM EFFECTS of marijuana use include addiction (psychological), paranoia, persistent anxiety, impaired learning skills and memory difficulties.

MEDICAL COMPLICATIONS associated with marijuana use include an increased risk of chronic cough, bronchitis, and emphysema; increased risk of cancer of the head, neck, and lungs; a decrease in testosterone levels and lower sperm counts for men and an increase in testosterone levels for women and increased risk of infertility.

Additional Information from NIDA:

* Within a few minutes after inhaling marijuana smoke, an individual's heart begins beating more rapidly, the bronchial passages relax and become enlarged, and blood vessels in the eyes expand, making the eyes look red. The heart rate, normally 70 to 80 beats per minute, may increase by 20 to 50 beats per minute or, in some cases, even double. This effect can be greater if other drugs are taken with marijuana.

* Studies show that approximately 6 to 11 percent of fatal accident victims test positive for THC. In many of these cases, alcohol is detected as well. In a study conducted by the National Highway Traffic Safety Administration, a moderate dose of marijuana alone was shown to impair driving performance; however, the effects of even a low dose of marijuana combined with alcohol were markedly greater than for either drug alone. Driving indices measured included reaction time, visual search frequency (driver checking side streets), and the ability to perceive and/or respond to changes in the relative velocity of other vehicles.

* Cancer of the respiratory tract and lungs may also be promoted by marijuana smoke. A study comparing 173 cancer patients and 176 healthy individuals produced strong evidence that smoking marijuana increases the likelihood of developing cancer of the head or neck, and that the more marijuana smoked, the greater the increase. A statistical analysis of the data suggested that marijuana smoking doubled or tripled the risk of these cancers.

* Marijuana has the potential to promote cancer of the lungs and other parts of the respiratory tract because it contains irritants and carcinogens.42 In fact, marijuana smoke contains 50 percent to 70 percent more carcinogenic hydrocarbons than does tobacco smoke.43 It also produces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form, levels that may accelerate the changes that ultimately produce malignant cells.44 Marijuana users usually inhale more deeply and hold their breath longer than tobacco smokers do, which increases the lungs' exposure to carcinogenic smoke. These facts suggest that, puff for puff, smoking marijuana may increase the risk of cancer more than smoking tobacco does.


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MDMA (Ecstasy)

MDMA (Ecstasy)

MDMA abuse and the trafficking of MDMA is on the rise, posing serious social concerns. Once confined to major metropolitan areas, MDMA trafficking has now expanded to smaller communities. Teenagers and young adults continue to be the primary targets of sophisticated crime syndicates who are supplying distribution groups with ever-increasing amounts of MDMA tablets. As the trend to consume MDMA in tandem with alcohol and other drugs continues, the harmful effects of the drug will increase exponentially.

MDMA (3,4-methylenedioxy-N-methylamphetamine), also referred to as Ecstasy, XTC, Adam, and Essence, is a illegally manufactured variation of mescaline and amphetamine. It is considered a designer drug---a substance on the drug market that is a chemical analogue or variation of another psychoactive drug.

MDMA is marketed as a feel good drug. Devotees say it produces profoundly positive feelings, empathy for others, elimination of anxiety, and extreme relaxation--hence the nickname "hug drug," or "love drug." MDMA is also said to suppress the need to eat, drink, or sleep, enabling club scene users to endure all-night and sometimes two, or three-day parties.

MDMA is taken orally, usually in tablet or capsule form. MDMA tablets are often "stamped" with icons or logos intended to appeal to a young audience. Its effects last approximately four to six hours.

Tablets sold as Ecstasy are not always pure MDMA. As demand for Ecstasy has increased, so has the appearance of Ecstasy "fakes" often containing other substances such as amphetamine, caffeine, codeine, DXM, ephedra/ephedrine, ketamine, MDA, methamphetamine, and PCP. When used alone, MDMA is dangerous. It is even more dangerous when used in combination with other substances, as the physical and psychological effects are difficult to determine or predict.

SHORT TERM EFFECTS: increased heart rate, blood pressure and body temperature; jaw and teeth clenching/muscle tension, hypertension, dehydration, chills and/or sweating, nausea, blurred vision, faintness, dizziness, confusion, insomnia, and paranoia.

MEDICAL COMPLICATIONS:

LARGE DOSE:
muscle breakdown, hyperthermia, kidney failure and cardiovascular system failure.

LONG TERM USE:
depression, sleep disorders, paranoia, drug craving, persistent elevation of anxiety, liver damage, brain damage, paralysis, and possible others pending research.

Domestically, the DEA seized 196 MDMA tablets in 1993 and more than 3 million tablets in 2000. The amount of seizures made by Customs has increased from 400,000 in FY 1997 to 7.2 million in FY 2001.
Source: DEA, U.S. Customs Service


In 2001, MDMA use among young people jumped an additional 20 percent. Since 1999, teen MDMA use increased by 71 percent. More than 12 percent of teens report trying MDMA at least once in their lives---an increase from 10% in 2000 (a year-to-year increase of 20 percent), 7 percent in 1999 (a 71 percent increase to date) and 5 percent in 1995---an increase of 140 percent from 1995 to 2001.
Source: 2001 Partnership Attitude Tracking Study

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